Anti-Mouse IL-10 R alpha Recombinant Antibody (1B1.3A) (MC614013)

Name: Anti-Mouse IL-10 R alpha Recombinant Antibody (1B1.3A)
Brand: abinScience
SKU: MC614013
Price: 191 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

50ug
100ug
1mg

수량:

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

MC614013

종 반응성

Mouse

응용 분야

ELISA, FCM, Functional assay, Research in vivo

숙주 종

Rat

클론성

Monoclonal

이소타입

IgG1, kappa

클론 ID

1B1.3A

타겟

CD210, CDw210a, IL-10 receptor subunit alpha, IL-10R subunit 1, IL-10R subunit alpha, IL-10R1, IL-10RA, IL10R, IL10RA, Interleukin-10 receptor subunit 1, Interleukin-10 receptor subunit alpha

내독소 수준

< 10 EU/mg

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

Q61727

형태

Liquid

저장 완충액

0.01M PBS pH 7.4.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Interleukin-10 receptor subunit alpha (CDw210a/IL10RA) is a ~64 kDa protein. Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes.

1. Weber-Nordt, RM. et al. (1996) The Journal of biological chemistry 271, 27954-61. PMID: 8910398

참고사항

For research use only

이미지

SDS-PAGE

SDS-PAGE for Anti-Mouse CDw210a/IL10RA Recombinant Antibody (1B1.3A)

참고 문헌

데이터시트

Anti-Mouse IL-10 R alpha Recombinant Antibody (1B1.3A).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse IL-10 R alpha Recombinant Antibody (1B1.3A) (MC614013)

개요

이미지

참고 문헌

데이터시트

SDS

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