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| 카탈로그 번호 | MC461014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse DSG2 Polyclonal Antibody (MC461014) is a rabbit polyclonal antibody detecting DSG2 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse DSG2 (Val61-Asn386). | ||||||||
| 타겟 | CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O55111 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Desmoglein-2 (DSG2) is a ~122 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells. 1. Eshkind, L. et al. (2002) European journal of cell biology 81, 592-8. PMID: 12494996 2. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125 3. Ebert, LM. et al. (2016) Angiogenesis 19, 463-86. PMID: 27338829 4. Kant, S. et al. (2015) Circulation. Cardiovascular genetics 8, 553-63. PMID: 26085008 5. Myo Min, KK. et al. (2022) Cell death & disease 13, 911. PMID: 36309486 6. Xu, T. et al. (2024) Kidney international 105, 1035-1048. PMID: 38395410 | ||||||||
| 참고사항 | For research use only. |
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