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| 카탈로그 번호 | MB825014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse FOLR1 Polyclonal Antibody (MB825014) is a rabbit polyclonal antibody detecting FOLR1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse FOLR1 (Asp53-Ser198). | ||||||||
| 타겟 | Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P35846 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere). 1. Brigle, KE. et al. (1991) The Journal of biological chemistry 266, 17243-9. PMID: 1894617 2. Piedrahita, JA. et al. (1999) Nature genetics 23, 228-32. PMID: 10508523 3. Tang, LS. et al. (2003) Birth defects research. Part A, Clinical and molecular teratology 67, 209-18. PMID: 12854656 4. Tang, LS. et al. (2004) Birth defects research. Part A, Clinical and molecular teratology 70, 449-58. PMID: 15259034 5. Zhu, H. et al. (2007) Birth defects research. Part A, Clinical and molecular teratology 79, 257-68. PMID: 17286298 6. Birn, H. et al. (2005) Journal of the American Society of Nephrology : JASN 16, 608-15. PMID: 15703271 | ||||||||
| 참고사항 | For research use only. |
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