Anti-Mouse GDF-15 Polyclonal Antibody (MV986014)

Name: Anti-Mouse GDF-15 Polyclonal Antibody
Brand: abinScience
SKU: MV986014
Price: 96 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

MV986014

설명

Anti-Mouse GDF-15 Polyclonal Antibody (MV986014) is a rabbit polyclonal antibody detecting GDF-15 in ELISA, IHC, WB. Suitable for Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse GDF15/MIC1 (Gly203-Ala303).

타겟

Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q9Z0J7

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Growth/differentiation factor 15 (GDF15/MIC1) is a ~33 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues.

1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844

2. Chung, HK. et al. (2017) The Journal of cell biology 216, 149-165. PMID: 27986797

3. Wang, T. et al. (2017) EMBO molecular medicine 9, 1150-1164. PMID: 28572090

4. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

5. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

6. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

7. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

8. Tsai, VW. et al. (2018) International journal of obesity (2005) 42, 561-571. PMID: 29026214

9. Xiong, Y. et al. (2017) Science translational medicine 9. PMID: 29046435

10. Patel, S. et al. (2019) Cell metabolism 29, 707-718.e8. PMID: 30639358

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Mouse GDF-15 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse GDF-15 Polyclonal Antibody (MV986014)

개요

이미지

참고 문헌

데이터시트

SDS

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