Anti-Mouse GFR alpha-like Polyclonal Antibody (MS720014)

Name: Anti-Mouse GFR alpha-like Polyclonal Antibody
Brand: abinScience
SKU: MS720014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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개요

카탈로그 번호

MS720014

설명

Anti-Mouse GFRAL Polyclonal Antibody (MS720014) is a rabbit polyclonal antibody detecting Gfral. Suitable for Mouse and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse GFRAL (Met128-Asn318).

타겟

GDNF family receptor alpha-like, Gfral, Gral

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q6SJE0

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

GDNF family receptor alpha-like (GFRAL) is a ~43 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem.

1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

5. Tsai, VW. et al. (2019) International journal of obesity (2005) 43, 2370-2380. PMID: 31152154

6. Borner, T. et al. (2020) Cell metabolism 31, 351-362.e5. PMID: 31928886

7. Worth, AA. et al. (2020) eLife 9. PMID: 32723474

8. Sabatini, PV. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33593916

9. Lu, JF. et al. (2022) PLoS biology 20, e3001517. PMID: 35202387

10. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Mouse GFR alpha-like Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse GFR alpha-like Polyclonal Antibody (MS720014)

개요

이미지

참고 문헌

데이터시트

SDS