中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | MW716014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse IFNAR2 Polyclonal Antibody (MW716014) is a rabbit polyclonal antibody detecting IFNAR2 in ELISA, IHC, WB. Suitable for Mus musculus.
Highlights
|
||||||||
| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse IFNAR2 (Thr40-Gln231). | ||||||||
| 타겟 | IFNAR2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O35664 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 대체 이름 | Ifnar2 protein, Type I interferon alpha/beta receptor 2a, Ifnar2 | ||||||||
| 배경 | Interferon alpha/beta receptor 2 (IFNAR2) is a ~56 kDa protein. Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-IFNAR2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: HepG2 cell lysate
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
