Anti-Mouse IRF3 Polyclonal Antibody (MC458014)

Name: Anti-Mouse IRF3 Polyclonal Antibody
Brand: abinScience
SKU: MC458014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

MC458014

설명

Anti-Mouse IRF3 Polyclonal Antibody (MC458014) is a rabbit polyclonal antibody detecting Irf3 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse IRF3 (Gln195-Ile419).

타겟

Interferon regulatory factor 3, IRF-3, Irf3

정제

Purified by antigen affinity column.

등록번호

P70671

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Interferon regulatory factor 3 (IRF3) is a ~46 kDa protein. Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes.

1. Honda, K. et al. (2005) Nature 434, 772-7. PMID: 15800576

2. Rao, Y. et al. (2025) Immunity 58, 74-89.e6. PMID: 39719712

3. Solis, M. et al. (2006) Biochemical pharmacology 72, 1469-76. PMID: 16846591

4. Honda, K. et al. (2006) Immunity 25, 349-60. PMID: 16979567

5. Savitsky, D. et al. (2010) Cancer immunology, immunotherapy : CII 59, 489-510. PMID: 20049431

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Mouse IRF3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse IRF3 Polyclonal Antibody (MC458014)

개요

이미지

참고 문헌

데이터시트

SDS