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| 카탈로그 번호 | MW360014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse LEP/Leptin (Val22-Cys167). | ||||||||
| 타겟 | Leptin, Obesity factor, Lep | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P41160 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Leptin is a ~18 kDa protein. Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. 1. Cowley, MA. et al. (2001) Nature 411, 480-4. PMID: 11373681 2. Bates, SH. et al. (2003) Nature 421, 856-9. PMID: 12594516 3. Otero, M. et al. (2005) Arthritis research & therapy 7, R581-91. PMID: 15899045 4. Gonzalez, RR. et al. (2006) The Journal of biological chemistry 281, 26320-8. PMID: 16825198 5. Ramadori, G. et al. (2010) Cell metabolism 12, 78-87. PMID: 20620997 6. Ducy, P. et al. (2000) Cell 100, 197-207. PMID: 10660043 7. Cassano, S. et al. (2014) Metabolism: clinical and experimental 63, 1272-9. PMID: 25060689 8. Flak, JN. et al. (2014) Nature neuroscience 17, 1744-1750. PMID: 25383904 9. Chehab, FF. et al. (1996) Nature genetics 12, 318-20. PMID: 8589726 | ||||||||
| 참고사항 | For research use only. |
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