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| 카탈로그 번호 | MA561013 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Mouse Mu-type opioid receptor/OPRM1/μOR Nanobody (SAA2285) [SAA2285] (MA561013) is a human monoclonal antibody detecting Mu-type opioid receptor in ELISA, IF, FCM. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse | ||||
| 응용 분야 | ELISA, IF, FCM | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-hFc | ||||
| 클론 ID | SAA2285 | ||||
| 타겟 | Mu-type opioid receptor, M-OR-1, MOR-1, Mu opiate receptor, Mu opioid receptor, MOP, hMOP, OPRM1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >90% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P42866 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Mu-type opioid receptor (OPRM1/μOR) is a ~44 kDa protein. Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. 1. George, SR. et al. (2000) The Journal of biological chemistry 275, 26128-35. PMID: 10842167 2. Rios, C. et al. (2006) British journal of pharmacology 148, 387-95. PMID: 16682964 3. Milan-Lobo, L. et al. (2011) The Journal of pharmacology and experimental therapeutics 337, 868-75. PMID: 21422164 4. Manglik, A. et al. (2012) Nature 485, 321-6. PMID: 22437502 5. Huang, W. et al. (2015) Nature 524, 315-21. PMID: 26245379 6. Kaufman, DL. et al. (1995) The Journal of biological chemistry 270, 15877-83. PMID: 7797593 7. Sora, I. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 1544-9. PMID: 9037090 8. Trieu, BH. et al. (2022) Science (New York, N.Y.) 375, 1177-1182. PMID: 35201898 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Mouse Mu-type opioid receptor/OPRM1/μOR Nanobody (SAA2285)
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