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| 카탈로그 번호 | MP446014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse PPARGC1A Polyclonal Antibody (MP446014) is a rabbit polyclonal antibody detecting peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b; Ppargc1a. Suitable for Rat, Human, and Mouse.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse PPARGC1A (Pro529-Arg797). | ||||||||
| 타겟 | peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b; Ppargc1a | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O70343 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a ~90 kDa protein. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program. 1. Puigserver, P. et al. (2003) Nature 423, 550-5. PMID: 12754525 2. Rodgers, JT. et al. (2005) Nature 434, 113-8. PMID: 15744310 3. Ruas, JL. et al. (2012) Cell 151, 1319-31. PMID: 23217713 4. Puigserver, P. et al. (1998) Cell 92, 829-39. PMID: 9529258 | ||||||||
| 참고사항 | For research use only |
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