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| 카탈로그 번호 | MV460014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse RIPK3 Polyclonal Antibody (MV460014) is a rabbit polyclonal antibody detecting Receptor-interacting serine/threonine-protein kinase 3; 2.7.11.1; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; mRIP3; Ripk3; Rip3 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant mouse RIPK3 (Met1-Leu320). | ||||||||
| 타겟 | Receptor-interacting serine/threonine-protein kinase 3; 2.7.11.1; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; mRIP3; Ripk3; Rip3 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9QZL0 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) is a ~53 kDa protein. Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death. Necroptosis, a programmed cell death process in response to death-inducing TNF family members, is triggered by RIPK3 following activation by ZBP1. Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity. 1. Nogusa, S. et al. (2016) Cell host & microbe 20, 13-24. PMID: 27321907 2. Thapa, RJ. et al. (2016) Cell host & microbe 20, 674-681. PMID: 27746097 3. Kuriakose, T. et al. (2016) Science immunology 1. PMID: 27917412 4. Sridharan, H. et al. (2017) EMBO reports 18, 1429-1441. PMID: 28607035 5. Zhang, T. et al. (2020) Cell 180, 1115-1129.e13. PMID: 32200799 6. Jiao, H. et al. (2020) Nature 580, 391-395. PMID: 32296175 7. Rebsamen, M. et al. (2009) EMBO reports 10, 916-22. PMID: 19590578 8. Upton, JW. et al. (2012) Cell host & microbe 11, 290-7. PMID: 22423968 9. Murphy, JM. et al. (2013) Immunity 39, 443-53. PMID: 24012422 10. Kaiser, WJ. et al. (2013) The Journal of biological chemistry 288, 31268-79. PMID: 24019532 | ||||||||
| 참고사항 | For research use only |
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