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| 카탈로그 번호 | MA318014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse ROBO3 Polyclonal Antibody (MA318014) is a rabbit polyclonal antibody detecting ROBO3 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse ROBO3 (Gly173-Val345). | ||||||||
| 타겟 | Roundabout-like protein 3, ROBO3, Roundabout homolog 3 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9Z2I4 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Roundabout homolog 3 (ROBO3) is a ~149 kDa protein. Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself. 1. Sabatier, C. et al. (2004) Cell 117, 157-69. PMID: 15084255 2. Chen, Z. et al. (2008) Neuron 58, 325-32. PMID: 18466743 3. Zelina, P. et al. (2014) Neuron 84, 1258-72. PMID: 25433640 4. Zhuang, M. et al. (2019) Nucleic acids research 47, 4765-4777. PMID: 30843071 5. Pak, JS. et al. (2020) Nature communications 11, 1489. PMID: 32198364 | ||||||||
| 참고사항 | For research use only. |
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