Anti-Mouse Siglec-10 Polyclonal Antibody (MV244014)

Name: Anti-Mouse Siglec-10 Polyclonal Antibody
Brand: abinScience
SKU: MV244014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

MV244014

설명

Anti-Mouse Siglec-10 Polyclonal Antibody (MV244014) is a rabbit polyclonal antibody detecting Siglec-10 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse SIGLEC10/SLG2 (Gln18-Ser528).

타겟

Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Sialic acid-binding Ig-like lectin G) (Siglec-G) (mSiglec-G)

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q80ZE3

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Sialic acid-binding Ig-like lectin 10 (SIGLEC10/SLG2) is a ~76 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling and specifically acts on B1 cells to inhibit Ca(2+) signaling, cellular expansion and antibody secretion.

1. Duong, BH. et al. (2010) The Journal of experimental medicine 207, 173-87. PMID: 20038598

2. Hoffmann, A. et al. (2007) Nature immunology 8, 695-704. PMID: 17572677

3. Pfrengle, F. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 1724-31. PMID: 23836061

4. Chen, GY. et al. (2009) Science (New York, N.Y.) 323, 1722-5. PMID: 19264983

5. Jellusova, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 3618-27. PMID: 20200274

6. Ding, Y. et al. (2016) Nature immunology 17, 1167-75. PMID: 27548433

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Mouse Siglec-10 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse Siglec-10 Polyclonal Antibody (MV244014)

개요

이미지

참고 문헌

데이터시트

SDS