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| 카탈로그 번호 | MX905014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse SLC16A1/MCT1 Polyclonal Antibody (MX905014) is a rabbit polyclonal antibody detecting Slc16a1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse SLC16A1/MCT1 (Met195-Arg254). | ||||||||
| 타겟 | Monocarboxylate transporter 1, MCT 1, Solute carrier family 16 member 1, Slc16a1, Mct1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P53986 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Monocarboxylate transporter 1 (SLC16A1/MCT1) is a ~53 kDa protein. Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. 1. Pullen, TJ. et al. (2012) Diabetes 61, 1719-25. PMID: 22522610 2. Lengacher, S. et al. (2013) PloS one 8, e82505. PMID: 24367518 3. Reddy, A. et al. (2020) Cell 183, 62-75.e17. PMID: 32946811 | ||||||||
| 참고사항 | For research use only. |
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