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| 카탈로그 번호 | MB247014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse TGM2 Polyclonal Antibody (MB247014) is a rabbit polyclonal antibody detecting TGM2 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse TGM2 (Asp151-Ala686). | ||||||||
| 타겟 | Protein-glutamine deamidase TGM2, TGase II, Heart G alpha(h), Erythrocyte transglutaminase, Protein-glutamine gamma-glutamyltransferase 2, TG(C), Transglutaminase C, Protein-glutamine serotonyltransferase TGM2, tTG, tTgase, Transglutaminase-2, Protein-glutamine noradrenalinyltransferase TGM2, TGM2, TG2, TGase C, Protein G alpha(h), Protein-glutamine histaminyltransferase TGM2, Tissue transglutaminase, hhG alpha(h), G(h), hTG2, Transglutaminase H, Protein-glutamine dopaminyltransferase TGM2, TGC, Isopeptidase TGM2, TGase-2, TGase H, Transglutaminase II | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P21981 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a ~77 kDa protein. Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. 1. De Laurenzi, V. et al. (2001) Molecular and cellular biology 21, 148-55. PMID: 11113189 2. Nanda, N. et al. (2001) The Journal of biological chemistry 276, 20673-8. PMID: 11274171 3. Santhanam, L. et al. (2010) Circulation research 107, 117-25. PMID: 20489165 4. Szondy, Z. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 7812-7. PMID: 12810961 5. Falasca, L. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 7330-40. PMID: 15905580 6. Liu, B. et al. (2019) Frontiers in pharmacology 10, 1611. PMID: 32116663 | ||||||||
| 참고사항 | For research use only. |
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