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| 카탈로그 번호 | MP042117 |
|---|---|
| 종 반응성 | Mouse |
| 응용 분야 | FCM |
| 숙주 종 | Rat |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | RMT4-53 |
| 접합 | FITC |
| 타겟 | TIMD4, T-cell immunoglobulin mucin receptor 4, TIM-4, TIMD-4, T-cell membrane protein 4, TIM4, T-cell immunoglobulin and mucin domain-containing protein 4 |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Rat IgG2a, kappa Recombinant Isotype Control Antibody (RTK2758), FITC |
| 등록번호 | Q6U7R4 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4/TIM-4) is a ~37 kDa protein. Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells. Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion. Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism. 1. Miyanishi, M. et al. (2007) Nature 450, 435-9. PMID: 17960135 2. Rodriguez-Manzanet, R. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 4706-13. PMID: 18354194 3. Mizui, M. et al. (2008) International immunology 20, 695-708. PMID: 18367551 4. Liu, W. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 990-1000. PMID: 31263038 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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