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| 카탈로그 번호 | HV725014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-MYOC Polyclonal Antibody (HV725014) is a rabbit polyclonal antibody detecting MYOC in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Cat, and Rat.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human MYOC (Ala224-Tyr471). | ||||||||
| 타겟 | MYOC, Myocilin, Trabecular meshwork-induced glucocorticoid response protein, GLC1A, TIGR, Myocilin 55 kDa subunit, Myocilin 35 kDa N-terminal fragment, Myocilin 20 kDa N-terminal fragment | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q99972 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Myocilin is a ~56 kDa protein. Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. | ||||||||
| 참고사항 | For research use only. |
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