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| 카탈로그 번호 | ZC081013 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Naja kaouthia Alpha-cobratoxin Nanobody (SAA2343) [SAA2343] (ZC081013) is a alpaca monoclonal antibody detecting Alpha-cobratoxin in ELISA, in vivo neutralization. Suitable for Naja kaouthia.
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| 종 반응성 | Naja kaouthia (Monocled cobra) | ||||
| 응용 분야 | ELISA, in vivo neutralization | ||||
| 숙주 종 | Alpaca | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-His | ||||
| 클론 ID | SAA2343 | ||||
| 타겟 | Alpha-cobratoxin, Alpha-CT, Alpha-CbT, Alpha-Cbtx, Alpha-Ctx, Alpha-elapitoxin-Nk2a, Alpha-EPTX-Nk2a, Long neurotoxin 1, Siamensis 3 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Purified by Nickel column. | ||||
| 등록번호 | P01391 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Alpha-cobratoxin is a ~7 kDa protein. Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA). 1. Osipov, AV. et al. (2008) The Journal of biological chemistry 283, 14571-80. PMID: 18381281 2. Osipov, AV. et al. (2012) The Journal of biological chemistry 287, 6725-34. PMID: 22223648 3. Servent, D. et al. (1997) The Journal of biological chemistry 272, 24279-86. PMID: 9305882 4. Kudryavtsev, DS. et al. (2015) The Journal of biological chemistry 290, 22747-58. PMID: 26221036 | ||||
| 참고사항 | For research use only |
SDS-PAGE for Anti-Naja kaouthia Alpha-cobratoxin Nanobody (SAA2343)
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