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| 카탈로그 번호 | HB136014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-NCF2 Polyclonal Antibody (HB136014) is a rabbit polyclonal antibody detecting NCF2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NCF2 (Lys355-Val526). | ||||||||
| 타겟 | Neutrophil NADPH oxidase factor 2, NOXA2, p67-phox, NADPH oxidase activator 2, 67 kDa neutrophil oxidase factor, Neutrophil cytosol factor 2, NCF-2, NCF2, P67PHOX | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P19878 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Neutrophil cytosol factor 2 (NCF2) is a ~59 kDa protein. Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. 1. Yoshida, L. et al. (2002) Biochemical and biophysical research communications 296, 1322-8. PMID: 12207919 2. Liu, X. et al. (2024) Nature 627, 189-195. PMID: 38355798 | ||||||||
| 참고사항 | For research use only. |
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