Anti-NCOA2 Polyclonal Antibody (HA816014)

Name: Anti-NCOA2 Polyclonal Antibody
Brand: abinScience
SKU: HA816014
Price: 96 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HA816014

설명

Anti-NCOA2 Polyclonal Antibody (HA816014) is a rabbit polyclonal antibody detecting Nuclear receptor coactivator 2; NCoA-2; Class E basic helix-loop-helix protein 75; bHLHe75; Transcriptional intermediary factor 2; hTIF2; NCOA2; BHLHE75; SRC2; TIF2 in ELISA, IHC, WB. Suitable for Human, Rat, and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human NCOA2 (Val109-Cys380).

타겟

Nuclear receptor coactivator 2; NCoA-2; Class E basic helix-loop-helix protein 75; bHLHe75; Transcriptional intermediary factor 2; hTIF2; NCOA2; BHLHE75; SRC2; TIF2

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q15596, Q9WUI9, Q61026

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Nuclear receptor coactivator 2 (NCOA2) is a ~159 kDa protein. Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3.

1. Druker, J. et al. (2013) Molecular and cellular biology 33, 2116-27. PMID: 23508108

2. Voegel, JJ. et al. (1996) The EMBO journal 15, 3667-75. PMID: 8670870

3. Voegel, JJ. et al. (1998) The EMBO journal 17, 507-19. PMID: 9430642

4. Musille, PM. et al. (2012) Nature structural & molecular biology 19, 532-S2. PMID: 22504882

5. Musille, PM. et al. (2016) The Journal of biological chemistry 291, 1411-26. PMID: 26553876

참고사항

For research use only

이미지

Western blot

Western blot analysis was performed using anti-NCOA2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: Jurkat cell lysate

참고 문헌

데이터시트

Anti-NCOA2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-NCOA2 Polyclonal Antibody (HA816014)

개요

이미지

참고 문헌

데이터시트

SDS

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