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| 카탈로그 번호 | HT177014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-NDC80/HEC1 Polyclonal Antibody (HT177014) is a rabbit polyclonal antibody detecting NDC80/HEC1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NDC80/HEC1 (Pro290-Glu642). | ||||||||
| 타겟 | HEC1, Kinetochore protein Hec1, HsHec1, HEC, Kinetochore protein NDC80 homolog, Kinetochore-associated protein 2, NDC80, Highly expressed in cancer protein, Retinoblastoma-associated protein HEC, KNTC2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O14777 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Kinetochore protein NDC80 homolog (HEC1) is a ~73 kDa protein. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules. 1. Martin-Lluesma, S. et al. (2002) Science (New York, N.Y.) 297, 2267-70. PMID: 12351790 2. DeLuca, JG. et al. (2003) Current biology : CB 13, 2103-9. PMID: 14654001 3. Bharadwaj, R. et al. (2004) The Journal of biological chemistry 279, 13076-85. PMID: 14699129 4. Joseph, J. et al. (2004) Current biology : CB 14, 611-7. PMID: 15062103 5. Stucke, VM. et al. (2004) Chromosoma 113, 1-15. PMID: 15235793 6. Meraldi, P. et al. (2004) Developmental cell 7, 45-60. PMID: 15239953 7. DeLuca, JG. et al. (2005) Molecular biology of the cell 16, 519-31. PMID: 15548592 8. Lin, YT. et al. (2006) Oncogene 25, 6901-14. PMID: 16732327 9. Zhao, G. et al. (2019) The Journal of biological chemistry 294, 576-592. PMID: 30409912 10. Chen, Y. et al. (1997) Molecular and cellular biology 17, 6049-56. PMID: 9315664 | ||||||||
| 참고사항 | For research use only. |
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