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| 카탈로그 번호 | JN824053 | ||||||
|---|---|---|---|---|---|---|---|
| 종 반응성 | Neisseria meningitidis | ||||||
| 응용 분야 | ELISA, WB | ||||||
| 숙주 종 | Human | ||||||
| 클론성 | Monoclonal | ||||||
| 이소타입 | IgG1, kappa | ||||||
| 클론 ID | SAA2741 | ||||||
| 타겟 | Factor H binding protein, GNA1870, Genome-derived Neisseria antigen 1870, LP2086, Lipoprotein 2086, fHbp, fhbP | ||||||
| 내독소 수준 | < 10 EU/mg | ||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||||
| 등록번호 | Q9JXV4 | ||||||
| 형태 | Liquid | ||||||
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 배경 | Factor H binding protein (FHBP) is a ~28 kDa protein. A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties. fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice. 1. Schneider, MC. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 7566-75. PMID: 16751403 2. Masignani, V. et al. (2003) The Journal of experimental medicine 197, 789-99. PMID: 12642606 3. Fletcher, LD. et al. (2004) Infection and immunity 72, 2088-100. PMID: 15039331 4. Giuliani, MM. et al. (2005) Infection and immunity 73, 1151-60. PMID: 15664958 5. Scarselli, M. et al. (2011) Science translational medicine 3, 91ra62. PMID: 21753121 6. Johnson, S. et al. (2012) PLoS pathogens 8, e1002981. PMID: 23133374 | ||||||
| 참고사항 | For research use only |
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