Anti-NOTCH2NLA Polyclonal Antibody (HV351014)

Name: Anti-NOTCH2NLA Polyclonal Antibody
Brand: abinScience
SKU: HV351014
Price: 168 USD
Availability: InStock

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개요
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SDS

개요

카탈로그 번호

HV351014

설명

Anti-NOTCH2NLA Polyclonal Antibody (HV351014) is a rabbit polyclonal antibody detecting NOTCH2NLA in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human NOTCH2NLA (Met1-Asn236).

타겟

Notch homolog 2 N-terminal-like protein A, NOTCH2NL, Notch homolog 2 N-terminal-like protein, N2N, NOTCH2NLA

정제

Purified by antigen affinity column.

등록번호

Q7Z3S9

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) is a ~25 kDa protein. Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation.

1. Florio, M. et al. (2018) eLife 7. PMID: 29561261

2. Fiddes, IT. et al. (2018) Cell 173, 1356-1369.e22. PMID: 29856954

3. Suzuki, IK. et al. (2018) Cell 173, 1370-1384.e16. PMID: 29856955

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-NOTCH2NLA Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-NOTCH2NLA Polyclonal Antibody (HV351014)

개요

이미지

참고 문헌

데이터시트

SDS

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