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| 카탈로그 번호 | HT011024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-NPC1 Polyclonal Antibody (HT011024) is a rabbit polyclonal antibody detecting NPC1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NPC1 (Arg372-Phe622). | ||||||||
| 타겟 | NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein, NPC1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O15118 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | NPC intracellular cholesterol transporter 1 (NPC1) is a ~142 kDa protein. Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). 1. Davies, JP. et al. (2000) The Journal of biological chemistry 275, 24367-74. PMID: 10821832 2. Blom, TS. et al. (2003) Human molecular genetics 12, 257-72. PMID: 12554680 3. Infante, RE. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15287-92. PMID: 18772377 4. Gong, X. et al. (2016) Cell 165, 1467-1478. PMID: 27238017 5. Carstea, ED. et al. (1997) Science (New York, N.Y.) 277, 228-31. PMID: 9211849 6. Watari, H. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 805-10. PMID: 9927649 7. Kwon, HJ. et al. (2009) Cell 137, 1213-24. PMID: 19563754 8. Ebrahimi-Fakhari, D. et al. (2016) Human molecular genetics 25, 3588-3599. PMID: 27378690 | ||||||||
| 참고사항 | For research use only. |
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