Anti-OAS1 Polyclonal Antibody (HF612014)

Name: Anti-OAS1 Polyclonal Antibody
Brand: abinScience
SKU: HF612014
Price: 168 USD
Availability: InStock

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개요
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SDS

개요

카탈로그 번호

HF612014

설명

Anti-OAS1 Polyclonal Antibody (HF612014) is a rabbit polyclonal antibody detecting OAS1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human OAS1 (Ser74-Pro165).

타겟

E18/E16, (2-5')oligo(A) synthase 1, 2-5A synthase 1, 2'-5'-oligoadenylate synthase 1, OAS1, OIAS, p46/p42 OAS

정제

Purified by antigen affinity column.

등록번호

P00973

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

2'-5'-oligoadenylate synthase 1 (OAS1) is a ~46 kDa protein. Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis.

1. Wickenhagen, A. et al. (2021) Science (New York, N.Y.) 374, eabj3624. PMID: 34581622

2. Magg, T. et al. (2021) Science immunology 6. PMID: 34145065

3. Huai, W. et al. (2025) Immunity 58, 797-810.e6. PMID: 40010341

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-OAS1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-OAS1 Polyclonal Antibody (HF612014)

개요

이미지

참고 문헌

데이터시트

SDS