Anti-OTUB1 Polyclonal Antibody (HV049014)

Name: Anti-OTUB1 Polyclonal Antibody
Brand: abinScience
SKU: HV049014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HV049014

설명

Anti-OTUB1 Polyclonal Antibody (HV049014) is a rabbit polyclonal antibody detecting OTUB1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human OTUB1 (Met1-Lys271).

타겟

OTU1, hOTU1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Deubiquitinating enzyme OTUB1, Otubain-1, OTUB1, Ubiquitin-specific-processing protease OTUB1, Ubiquitin thioesterase OTUB1, OTB1

정제

Purified by antigen affinity column.

등록번호

Q96FW1

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Ubiquitin thioesterase OTUB1 is a ~31 kDa protein. Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy.

1. Borodovsky, A. et al. (2002) Chemistry & biology 9, 1149-59. PMID: 12401499

2. Balakirev, MY. et al. (2003) EMBO reports 4, 517-22. PMID: 12704427

3. Soares, L. et al. (2004) Nature immunology 5, 45-54. PMID: 14661020

4. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681

5. Stanišić, V. et al. (2009) The Journal of biological chemistry 284, 16135-16145. PMID: 19383985

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-OTUB1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-OTUB1 Polyclonal Antibody (HV049014)

개요

이미지

참고 문헌

데이터시트

SDS