Anti-PAK2 Polyclonal Antibody (HC597014)

Name: Anti-PAK2 Polyclonal Antibody
Brand: abinScience
SKU: HC597014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HC597014

설명

Anti-PAK2 Polyclonal Antibody (HC597014) is a rabbit polyclonal antibody detecting PAK2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PAK2 (Glu177-Ala419).

타겟

S6/H4 kinase, p21-activated kinase 2, p58, PAK-2, PAK2, C-t-PAK2, PAK65, p34, Gamma-PAK, Serine/threonine-protein kinase PAK 2, p27

정제

Purified by antigen affinity column.

등록번호

Q13177

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Serine/threonine-protein kinase PAK 2 (PAK2) is a ~58 kDa protein. Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.

1. Jakobi, R. et al. (2003) The Journal of biological chemistry 278, 38675-85. PMID: 12853446

2. Vilas, GL. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 6542-7. PMID: 16617111

3. Mitsushima, M. et al. (2009) Molecular and cellular biology 29, 2816-27. PMID: 19273597

4. Hsu, RM. et al. (2010) Molecular biology of the cell 21, 287-301. PMID: 19923322

5. Antonarakis, SE. et al. (2021) Human molecular genetics 31, 1-9. PMID: 33693784

6. Martin, GA. et al. (1995) The EMBO journal 14, 1970-8. PMID: 7744004

7. Rudel, T. et al. (1997) Science (New York, N.Y.) 276, 1571-4. PMID: 9171063

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-PAK2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

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어세이 키트

Anti-PAK2 Polyclonal Antibody (HC597014)

개요

이미지

참고 문헌

데이터시트

SDS