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| 카탈로그 번호 | HX975014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PAX5 (Met1-His391). | ||||||||
| 타겟 | B-cell-specific transcription factor, Paired box protein Pax-5, BSAP, PAX5 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q02548 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Paired box protein Pax-5 (PAX5) is a ~42 kDa protein. Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire. 1. Eberhard, D. et al. (2000) The EMBO journal 19, 2292-303. PMID: 10811620 2. Inagaki, Y. et al. (2016) Biochemical and biophysical research communications 475, 176-81. PMID: 27181361 3. Hill, L. et al. (2020) Nature 584, 142-147. PMID: 32612238 | ||||||||
| 참고사항 | For research use only. |
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