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| 카탈로그 번호 | HV421024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-PDCD6IP Polyclonal Antibody (HV421024) is a rabbit polyclonal antibody detecting Programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95; PDCD6IP; AIP1; ALIX; KIAA1375 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human PDCD6IP (Met1-Ala392). | ||||||||
| 타겟 | Programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95; PDCD6IP; AIP1; ALIX; KIAA1375 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q8WUM4, Q9WU78, Q9QZA2 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Programmed cell death 6-interacting protein (PDCD6IP) is a ~96 kDa protein. Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. 1. Matsuo, H. et al. (2004) Science (New York, N.Y.) 303, 531-4. PMID: 14739459 2. Carlton, JG. et al. (2007) Science (New York, N.Y.) 316, 1908-12. PMID: 17556548 3. Morita, E. et al. (2007) The EMBO journal 26, 4215-27. PMID: 17853893 4. Carlton, JG. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 10541-6. PMID: 18641129 5. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413 | ||||||||
| 참고사항 | For research use only |
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