Anti-PGAM5 Polyclonal Antibody (HB500014)

Name: Anti-PGAM5 Polyclonal Antibody
Brand: abinScience
SKU: HB500014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HB500014

설명

Anti-PGAM5 Polyclonal Antibody (HB500014) is a rabbit polyclonal antibody detecting Serine/threonine-protein phosphatase PGAM5 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human PGAM5 (Ala94-Ser289).

타겟

Serine/threonine-protein phosphatase PGAM5, mitochondrial; 3.1.3.16; Bcl-XL-binding protein v68; Phosphoglycerate mutase family member 5; PGAM5

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q96HS1, Q8BX10, Q562B5

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Serine/threonine-protein phosphatase PGAM5, mitochondrial is a ~32 kDa protein. Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy. Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1. Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation. Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3.

1. Chen, G. et al. (2014) Molecular cell 54, 362-77. PMID: 24746696

2. Yu, B. et al. (2020) Nature communications 11, 2549. PMID: 32439975

3. Nag, S. et al. (2023) Cell reports 42, 112895. PMID: 37498743

4. Lo, SC. et al. (2008) Experimental cell research 314, 1789-803. PMID: 18387606

5. Wang, Z. et al. (2012) Cell 148, 228-43. PMID: 22265414

참고사항

For research use only

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참고 문헌

데이터시트

Anti-PGAM5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-PGAM5 Polyclonal Antibody (HB500014)

개요

이미지

참고 문헌

데이터시트

SDS