Anti-PHLPP2 Polyclonal Antibody (HB456014)

Name: Anti-PHLPP2 Polyclonal Antibody
Brand: abinScience
SKU: HB456014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HB456014

설명

Anti-PHLPP2 Polyclonal Antibody (HB456014) is a rabbit polyclonal antibody detecting PH domain leucine-rich repeat-containing protein phosphatase 2; 3.1.3.16; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like; PHLPP2; KIAA0931; PHLPPL in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human PHLPP2 (Leu97-Val247).

타겟

PH domain leucine-rich repeat-containing protein phosphatase 2; 3.1.3.16; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like; PHLPP2; KIAA0931; PHLPPL

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q6ZVD8, Q8BXA7

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2) is a ~146 kDa protein. Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3.

1. Qiao, M. et al. (2010) Molecular cell 38, 512-23. PMID: 20513427

2. Liu, J. et al. (2011) Molecular and cellular biology 31, 4917-27. PMID: 21986499

3. Li, X. et al. (2014) Gastroenterology 146, 1301-12.e1-10. PMID: 24530606

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-PHLPP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-PHLPP2 Polyclonal Antibody (HB456014)

개요

이미지

참고 문헌

데이터시트

SDS

빠른 접근

문의하기