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| 카탈로그 번호 | MB610013 | ||||||
|---|---|---|---|---|---|---|---|
| 브랜드 | abinScience | ||||||
| 종 반응성 | Human, Mouse, Rat, AKT8 murine leukemia virus | ||||||
| 응용 분야 | ELISA, IHC, IP, WB | ||||||
| 숙주 종 | Rat | ||||||
| 클론성 | Monoclonal | ||||||
| 이소타입 | IgG1, kappa | ||||||
| 클론 ID | P8.H9 | ||||||
| 타겟 | RAC-alpha serine/threonine-protein kinase, RAC, RAC-PK-alpha, PKB alpha, Proto-oncogene c-Akt, Protein kinase B alpha, Protein kinase B, AKT1, PKB | ||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||||
| 등록번호 | P31749 | ||||||
| 형태 | Liquid | ||||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 배경 | RAC-alpha serine/threonine-protein kinase (p-AKT1) is a ~55 kDa protein. AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. 1. Nicholson, KM. et al. (2002) Cellular signalling 14, 381-95. PMID: 11882383 2. Rönnstrand, L. (2004) Cellular and molecular life sciences : CMLS 61, 2535-48. PMID: 15526160 3. Cartlidge, RA. et al. (2005) The EMBO journal 24, 1696-705. PMID: 15861136 4. Heron-Milhavet, L. et al. (2011) Histology and histopathology 26, 651-62. PMID: 21432781 5. Hers, I. et al. (2011) Cellular signalling 23, 1515-27. PMID: 21620960 6. Walia, V. et al. (2019) Developmental cell 50, 229-246.e7. PMID: 31204173 7. Choppara, S. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 998-1003. PMID: 29343641 | ||||||
| 참고사항 | For research use only. | ||||||
| Isotype Control | Rat IgG1, kappa Recombinant Isotype Control Antibody (RTK2071) (RV080407) |
SDS-PAGE for Anti-Phospho-AKT1 (pS473) Antibody (P8.H9).
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