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| 카탈로그 번호 | HT447023 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | IHC, IP, WB | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA0299 | ||||
| 타겟 | High temperature requirement protein A2, OMI, HtrA2, PRSS25, Serine protease 25, Serine proteinase OMI, Serine protease HTRA2, mitochondrial, HTRA2, Omi stress-regulated endoprotease | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | O43464 | ||||
| RRID | Anti-Phospho-HTRA2 (pS212) Antibody (SAA0299) (abinScience Cat# HT447023, RRID:AB_3725756) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Serine protease HTRA2, mitochondrial (pHTRA2) is a ~48 kDa protein. Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis. 1. Savopoulos, JW. et al. (2000) Protein expression and purification 19, 227-34. PMID: 10873535 2. Bartke, T. et al. (2004) Molecular cell 14, 801-11. PMID: 15200957 3. Hunkeler, M. et al. (2023) Science (New York, N.Y.) 379, 1105-1111. PMID: 36758104 4. Ehrmann, JF. et al. (2023) Science (New York, N.Y.) 379, 1117-1123. PMID: 36758105 5. Balakrishnan, MP. et al. (2009) American journal of physiology. Heart and circulatory physiology 297, H643-53. PMID: 19502560 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Phospho-HTRA2 (pS212) Antibody (SAA0299)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
