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| 카탈로그 번호 | HV616014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-PIK3C3 Polyclonal Antibody (HV616014) is a rabbit polyclonal antibody detecting PIK3C3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Pig, and Xenopus laevis.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PIK3C3 (Tyr631-Trp885). | ||||||||
| 타겟 | PtdIns-3-kinase type 3, Phosphatidylinositol 3-kinase p100 subunit, hVps34, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphoinositide-3-kinase class 3, PI3-kinase type 3, VPS34, PI3K type 3, PIK3C3 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q8NEB9 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) is a ~101 kDa protein. Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes. 1. Stein, MP. et al. (2003) Traffic (Copenhagen, Denmark) 4, 754-71. PMID: 14617358 2. Chen, YH. et al. (2021) Nature communications 12, 1322. PMID: 33637724 3. Volinia, S. et al. (1995) The EMBO journal 14, 3339-48. PMID: 7628435 4. Zhang, BC. et al. (2020) Nature immunology 21, 868-879. PMID: 32690950 5. Sagona, AP. et al. (2010) Nature cell biology 12, 362-71. PMID: 20208530 6. Thoresen, SB. et al. (2010) Experimental cell research 316, 3368-78. PMID: 20643123 | ||||||||
| 참고사항 | For research use only. |
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