Anti-PLK4 Polyclonal Antibody (HT163014)

Name: Anti-PLK4 Polyclonal Antibody
Brand: abinScience
SKU: HT163014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HT163014

설명

Anti-PLK4 Polyclonal Antibody (HT163014) is a rabbit polyclonal antibody detecting PLK4 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Pongo abelii, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PLK4 (Met1-Pro263).

타겟

PLK-4, Serine/threonine-protein kinase Sak, Serine/threonine-protein kinase PLK4, STK18, PLK4, Polo-like kinase 4, Serine/threonine-protein kinase 18, SAK

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O00444

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Serine/threonine-protein kinase PLK4 is a ~108 kDa protein. Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors.

1. Tang, CJ. et al. (2011) The EMBO journal 30, 4790-804. PMID: 22020124

2. Denu, RA. et al. (2019) The Journal of biological chemistry 294, 6531-6549. PMID: 30804208

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-PLK4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-PLK4 Polyclonal Antibody (HT163014)

개요

이미지

참고 문헌

데이터시트

SDS

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