Anti-PSEN2 Polyclonal Antibody (HW821014)

Name: Anti-PSEN2 Polyclonal Antibody
Brand: abinScience
SKU: HW821014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HW821014

설명

Anti-PSEN2 Polyclonal Antibody (HW821014) is a rabbit polyclonal antibody detecting Presenilin-2; PS-2; 3.4.23.-; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit; PSEN2; AD4; PS2; PSNL2; STM2 in ELISA, IHC, WB. Suitable for Human, Pig, Bovine, Rat, and Frog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human PSEN2 (Lys271-Lys361).

타겟

Presenilin-2; PS-2; 3.4.23.-; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit; PSEN2; AD4; PS2; PSNL2; STM2

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P49810, Q0MS45, Q9XT96, O88777, O12977, Q61144

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.

1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236

2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302

3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394

4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189

5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978

6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576

7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-PSEN2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-PSEN2 Polyclonal Antibody (HW821014)

개요

이미지

참고 문헌

데이터시트

SDS

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