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| 카탈로그 번호 | JN076034 | ||||||||
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| 설명 |
Anti-Pseudomonas aeruginosa impA Polyclonal Antibody (JN076034) is a rabbit polyclonal antibody detecting IMPa. Suitable for Pseudomonas aeruginosa.
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| 종 반응성 | Pseudomonas aeruginosa | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Pseudomonas aeruginosa impA (Ala42-Pro923). | ||||||||
| 타겟 | EC:3.4.24.-, IMPa, Immunomodulating metalloprotease, impA | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9I5W4 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Immunomodulating metalloprotease (impA) is a ~100 kDa protein. Protease that degrades several proteins of the host immune system. Cleaves P-selectin glycoprotein ligand-1 (PSGL-1), leading to its functional inhibition; PSGL-1 is a leukocyte cell-surface receptor essential for leukocyte recruitment to the site of infection. Next to PSGL-1, targets host CD43 and CD44 that are also involved in leukocyte homing. Thus, prevents neutrophil extravasation and thereby protects P.aeruginosa from neutrophil attack. Is also able to inhibit the decay accelerating factor (CD55), but not the cell-surface receptors CD46 and CD31. | ||||||||
| 참고사항 | For research use only |
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