Anti-PTPN11 Polyclonal Antibody (HC400014)

Name: Anti-PTPN11 Polyclonal Antibody
Brand: abinScience
SKU: HC400014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HC400014

설명

Anti-PTPN11 Polyclonal Antibody (HC400014) is a rabbit polyclonal antibody detecting PTPN11 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PTPN11 (Met1-Arg593).

타겟

Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-2C, Shp2, SHP-2, SH-PTP3, Protein-tyrosine phosphatase 2C, PTP2C, PTP-1D, PTPN11, SHPTP2, SH-PTP2

정제

Purified by antigen affinity column.

등록번호

Q06124

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) is a ~68 kDa protein. Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73.

1. Miao, H. et al. (2000) Nature cell biology 2, 62-9. PMID: 10655584

2. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280

3. Lee, HH. et al. (2008) The Journal of cell biology 181, 999-1012. PMID: 18559669

4. Jakob, S. et al. (2008) The Journal of biological chemistry 283, 33155-61. PMID: 18829466

5. Noda, S. et al. (2016) Biochemical and biophysical research communications 469, 1133-9. PMID: 26742426

6. Pannone, L. et al. (2017) Human mutation 38, 451-459. PMID: 28074573

7. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-PTPN11 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-PTPN11 Polyclonal Antibody (HC400014)

개요

이미지

참고 문헌

데이터시트

SDS