Anti-PTPN6 Polyclonal Antibody (HB806014)

Name: Anti-PTPN6 Polyclonal Antibody
Brand: abinScience
SKU: HB806014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HB806014

설명

Anti-PTPN6 Polyclonal Antibody (HB806014) is a rabbit polyclonal antibody detecting PTPN6 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PTPN6 (Phe244-Phe515).

타겟

HCP, PTPN6, PTP1C, Hematopoietic cell protein-tyrosine phosphatase, SH-PTP1, Protein-tyrosine phosphatase SHP-1, Protein-tyrosine phosphatase 1C, Tyrosine-protein phosphatase non-receptor type 6, PTP-1C

정제

Purified by antigen affinity column.

등록번호

P29350

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) is a ~67 kDa protein. Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis. Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities. When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events. Modulates the signaling of several cytokine receptors including IL-4 receptor. Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling.

1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280

2. Aki, D. et al. (2018) Nature immunology 19, 766-775. PMID: 29925997

3. Hsu, JM. et al. (2011) Nature cell biology 13, 174-81. PMID: 21258366

4. Keilhack, H. et al. (1998) The Journal of biological chemistry 273, 24839-46. PMID: 9733788

5. Bellón, T. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 3351-9. PMID: 11907092

6. Velasco Cárdenas, RM. et al. (2023) Nature immunology 24, 2135-2149. PMID: 37932456

7. Poirier, A. et al. (2024) Science signaling 17, eadg4422. PMID: 38166031

8. Imani, F. et al. (1997) The Journal of biological chemistry 272, 7927-31. PMID: 9065461

9. Wang, Y. et al. (2022) Cellular & molecular immunology 19, 108-121. PMID: 34811497

10. Chyuan, IT. et al. (2024) Journal of biomedical science 31, 33. PMID: 38532423

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-PTPN6 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-PTPN6 Polyclonal Antibody (HB806014)

개요

이미지

참고 문헌

데이터시트

SDS