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| 카탈로그 번호 | TC588013 |
|---|---|
| 종 반응성 | Rabbit |
| 응용 분야 | IHC |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a |
| 클론 ID | L57/23R |
| 타겟 | Target name:CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1, Voltage-dependent L-type calcium channel subunit alpha-1C, Calcium channel L type alpha-1 polypeptide, Smooth muscle calcium channel blocker receptor, CACB-receptor, Voltage-gated calcium channel subunit alpha Cav1.2 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P15381 |
| RRID | Anti-Rabbit CACNA1C Antibody (L57/23R) (abinScience Cat# TC588013, RRID:AB_3726996) |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) is a ~242 kDa protein. Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. 1. Cohen, RM. et al. (2005) American journal of physiology. Heart and circulatory physiology 288, H2363-74. PMID: 15615847 2. Yada, H. et al. (2007) Circulation research 101, 69-77. PMID: 17525370 3. Yang, L. et al. (2011) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25, 928-36. PMID: 21127204 4. Biel, M. et al. (1990) FEBS letters 269, 409-12. PMID: 2169433 5. Almagor, L. et al. (2012) The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 7602-13. PMID: 22649239 6. Nakada, T. et al. (2012) The Biochemical journal 448, 221-31. PMID: 22928916 7. Gez, LS. et al. (2012) Biochemistry 51, 9658-66. PMID: 23145875 8. Mikami, A. et al. (1989) Nature 340, 230-3. PMID: 2474130 9. Campiglio, M. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 1376-1381. PMID: 29363593 10. Yang, J. et al. (1993) Nature 366, 158-61. PMID: 8232554 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Rabbit CACNA1C Antibody (L57/23R)
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