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| 카탈로그 번호 | HV665014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-RAD54L2 Polyclonal Antibody (HV665014) is a rabbit polyclonal antibody detecting RAD54L2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RAD54L2 (Ala638-Ser837). | ||||||||
| 타겟 | Androgen receptor-interacting protein 4, KIAA0809, Helicase ARIP4, ARIP4, RAD54L2, RAD54-like protein 2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9Y4B4 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Helicase ARIP4 (RAD54L2) is a ~162 kDa protein. Helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. May stimulate the release of RNA polymerase II, that has paused near the transcription start sites of AR-targeted genes and unwind R-loops formed at these sites; R-loops result from the hybridization of the short RNA strand nascently synthesized by the paused RNA polymerase II molecule and the DNA template. May also stimulate double-strand break formation by TOP2B, which appears important for transcriptional output. Not able to remodel mononucleosomes in vitro. 1. Ng, RR. et al. (2024) Science advances 10, eadm9577. PMID: 39028815 | ||||||||
| 참고사항 | For research use only. |
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