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| 카탈로그 번호 | HY483014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-RARA Polyclonal Antibody (HY483014) is a rabbit polyclonal antibody detecting RARA in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Coturnix japonica, and Danio rerio.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RARA (Ser68-Glu173). | ||||||||
| 타겟 | RARA, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1, RAR-alpha, NR1B1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P10276 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Retinoic acid receptor alpha (RARA) is a ~50 kDa protein. Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. 1. Srinivas, H. et al. (2006) The Biochemical journal 395, 653-62. PMID: 16417524 2. Zhu, L. et al. (2009) Endocrinology 150, 5586-95. PMID: 19850744 3. Santos, NC. et al. (2010) Endocrinology 151, 2361-72. PMID: 20215566 4. Sato, Y. et al. (2010) PloS one 5, e15119. PMID: 21152046 5. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846 6. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758 7. Qin, Z. et al. (2009) Molecular and cellular biology 29, 3633-43. PMID: 19398580 | ||||||||
| 참고사항 | For research use only. |
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