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| 카탈로그 번호 | HV607014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-RARRES2 Polyclonal Antibody (HV607014) is a rabbit polyclonal antibody detecting RARRES2 in ELISA, IHC, WB. Suitable for Human and Pongo abelii.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RARRES2 (Ala33-Lys158). | ||||||||
| 타겟 | Chemerin, Retinoic acid receptor responder protein 2, Tazarotene-induced gene 2 protein, RAR-responsive protein TIG2, TIG2, RARRES2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q99969 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Retinoic acid receptor responder protein 2 (RARRES2) is a ~18 kDa protein. Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Also acts as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2. Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. 1. De Henau, O. et al. (2016) PloS one 11, e0164179. PMID: 27716822 | ||||||||
| 참고사항 | For research use only. |
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