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| 카탈로그 번호 | RV329033 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Rat ARC Nanobody (E5#) [E5#] (RV329033) is a alpaca monoclonal antibody detecting Arc in ELISA, Neutralization. Suitable for Rat.
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| 종 반응성 | Rat | ||||
| 응용 분야 | ELISA, Neutralization | ||||
| 숙주 종 | Alpaca | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-Avi-8His-Cys-tag | ||||
| 클론 ID | E5# | ||||
| 타겟 | Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein, ARC/ARG3.1, Arg3.1, Arc | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Purified by Nickel column. | ||||
| 등록번호 | Q63053 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Activity-regulated cytoskeleton-associated protein (ARC) is a ~45 kDa protein. Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. 1. Pastuzyn, ED. et al. (2018) Cell 172, 275-288.e18. PMID: 29328916 2. Guzowski, JF. et al. (2000) The Journal of neuroscience : the official journal of the Society for Neuroscience 20, 3993-4001. PMID: 10818134 3. Chowdhury, S. et al. (2006) Neuron 52, 445-59. PMID: 17088211 4. Rial Verde, EM. et al. (2006) Neuron 52, 461-74. PMID: 17088212 5. Shepherd, JD. et al. (2006) Neuron 52, 475-84. PMID: 17088213 6. Mikuni, T. et al. (2013) Neuron 78, 1024-35. PMID: 23791196 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Rat ARC Nanobody (E5#)
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