Anti-Rat CASR Polyclonal Antibody (RW613014)

Name: Anti-Rat CASR Polyclonal Antibody
Brand: abinScience
SKU: RW613014
Price: 168 USD
Availability: InStock

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사양:

50ug
100ug

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호

RW613014

설명

Anti-Rat CASR Polyclonal Antibody (RW613014) is a rabbit polyclonal antibody detecting CaSR. Suitable for Rat and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Rat CASR (Lys863-Ser1079).

타겟

CaSR, Casr, Extracellular calcium-sensing receptor, Gprc2a, PCaR1, Parathyroid cell calcium-sensing receptor, Pcar1, RaKCaR

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P48442

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Extracellular calcium-sensing receptor (CASR) is a ~120 kDa protein. G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands. In kidneys, acts as a key regulator of renal tubular calcium resorption. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of downstream effectors. CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G-proteins depending on the context.

1. Loupy, A. et al. (2012) The Journal of clinical investigation 122, 3355-67. PMID: 22886306

2. Riccardi, D. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 131-5. PMID: 7816802

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Rat CASR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Rat CASR Polyclonal Antibody (RW613014)

개요

이미지

참고 문헌

데이터시트

SDS