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| 카탈로그 번호 | HY189014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-RB1 Polyclonal Antibody (HY189014) is a rabbit polyclonal antibody detecting RB1 in ELISA, IHC, WB. Suitable for Mouse, Human, and Rat.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RB1 (Gln639-Thr778). | ||||||||
| 타겟 | pRb, p110-RB1, Retinoblastoma-associated protein, Rb, p105-Rb, RB1, pp110 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P06400 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Retinoblastoma-associated protein (RB1) is a ~106 kDa protein. Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. 1. Harbour, JW. et al. (1999) Cell 98, 859-69. PMID: 10499802 2. Ren, S. et al. (2004) Cell 117, 239-51. PMID: 15084261 | ||||||||
| 참고사항 | For research use only. |
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