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| 카탈로그 번호 | HB545014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-RBM33 Polyclonal Antibody (HB545014) is a rabbit polyclonal antibody detecting RNA-binding protein 33; Proline-rich protein 8; RNA-binding motif protein 33; RBM33; PRR8 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human RBM33 (Gln1096-Glu1170). | ||||||||
| 타겟 | RNA-binding protein 33; Proline-rich protein 8; RNA-binding motif protein 33; RBM33; PRR8 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q96EV2, Q9CXK9 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | RNA-binding protein 33 (RBM33) is a ~129 kDa protein. RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation. 1. Thomas, A. et al. (2022) Genes & development 36, 550-565. PMID: 35589130 2. Yu, F. et al. (2023) Molecular cell 83, 2003-2019.e6. PMID: 37257451 | ||||||||
| 참고사항 | For research use only |
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