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| 카탈로그 번호 | HC013014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-RNF126 Polyclonal Antibody (HC013014) is a rabbit polyclonal antibody detecting RNF126 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant RNF126 (Met1-Ser311). | ||||||||
| 타겟 | E3 ubiquitin-protein ligase RNF126, EC:2.3.2.27, RING finger protein 126, RNF126 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 관찰된 분자량 | ~40 kDa | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9BV68, Q91YL2, Q0II22 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | E3 ubiquitin-protein ligase RNF126 is a ~33 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-27'-, 'Lys-29'-, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. 1. Delker, RK. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 1029-34. PMID: 23277564 2. Smith, CJ. et al. (2014) Experimental cell research 320, 219-32. PMID: 24275455 3. Rodrigo-Brenni, MC. et al. (2014) Molecular cell 55, 227-37. PMID: 24981174 4. Liu, W. et al. (2023) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10, e2203884. PMID: 36563124 5. Mock, JY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 11679-11684. PMID: 29042515 6. Smith, CJ. et al. (2013) Journal of cell science 126, 1366-80. PMID: 23418353 7. Zhi, X. et al. (2013) Cancer research 73, 385-94. PMID: 23026136 | ||||||||
| 참고사항 | For research use only |
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