Anti-RORC/NR1F3/RORgT Polyclonal Antibody (HW351014)

Name: Anti-RORC/NR1F3/RORgT Polyclonal Antibody
Brand: abinScience
SKU: HW351014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HW351014

설명

Anti-RORC/NR1F3/RORgT Polyclonal Antibody (HW351014) is a rabbit polyclonal antibody detecting NR1F3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human RORC/NR1F3/RORgT (Glu212-Ser461).

타겟

RAR-related orphan receptor C, RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Retinoid-related orphan receptor-gamma, RZRG, Nuclear receptor subfamily 1 group F member 3, RORG, RORgT

정제

Purified by antigen affinity column.

등록번호

P51449

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Nuclear receptor ROR-gamma (RORC/NR1F3) is a ~58 kDa protein. Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner.

1. Jetten, AM. (2009) Nuclear receptor signaling 7, e003. PMID: 19381306

2. Wang, Y. et al. (2010) The Journal of biological chemistry 285, 5013-25. PMID: 19965867

3. Jin, L. et al. (2010) Molecular endocrinology (Baltimore, Md.) 24, 923-9. PMID: 20203100

4. Solt, LA. et al. (2012) Trends in endocrinology and metabolism: TEM 23, 619-27. PMID: 22789990

5. Okada, S. et al. (2015) Science (New York, N.Y.) 349, 606-613. PMID: 26160376

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-RORC/NR1F3/RORgT Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-RORC/NR1F3/RORgT Polyclonal Antibody (HW351014)

개요

이미지

참고 문헌

데이터시트

SDS

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