Anti-RUNX1/RUNX2/RUNX3 Polyclonal Antibody (HX866014)

Name: Anti-RUNX1/RUNX2/RUNX3 Polyclonal Antibody
Brand: abinScience
SKU: HX866014
Price: 168 USD
Availability: InStock

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사양:

50ug
100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HX866014

설명

Anti-RUNX1/RUNX2/RUNX3 Polyclonal Antibody (HX866014) is a rabbit polyclonal antibody detecting RUNX1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human RUNX1 (Met1-Tyr480).

타겟

Isoform AML-1G of Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, RUNX1, AML1, CBFA2

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q01196, Q63046, Q03347, Q6PF39, Q13950, Q9Z2J9, Q08775, Q13761, Q64131

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Runt-related transcription factor 1 is a ~48 kDa protein. Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter.

1. Fujimoto, T. et al. (2007) The EMBO journal 26, 2361-70. PMID: 17431401

2. Mao, S. et al. (1999) Molecular and cellular biology 19, 3635-44. PMID: 10207087

3. Cho, JY. et al. (2004) The Journal of biological chemistry 279, 19512-22. PMID: 14970218

4. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-RUNX1/RUNX2/RUNX3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-RUNX1/RUNX2/RUNX3 Polyclonal Antibody (HX866014)

개요

이미지

참고 문헌

데이터시트

SDS